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Showing 1–6 of 6 results
Advanced filters: Author: Mathias Lechner Clear advanced filters
  • Inspired by the brain of the roundworm Caenorhabditis elegans, the authors design a highly compact neural network controller directly from raw input pixels. Compared with larger networks, this compact controller demonstrates improved generalization, robustness and interpretability on a lane-keeping task.

    • Mathias Lechner
    • Ramin Hasani
    • Radu Grosu
    Research
    Nature Machine Intelligence
    Volume: 2, P: 642-652
  • Lechner et al. used an affinity-based chemical proteomics approach to investigate the target landscape of HDAC inhibitors, and identified an extracellular vesicle regulator MBLAC2 as a universal off-target of 24 hydroxamate inhibitors.

    • Severin Lechner
    • Martin Ian P. Malgapo
    • Guillaume Médard
    Research
    Nature Chemical Biology
    Volume: 18, P: 812-820
  • Physical dynamical processes can be modelled with differential equations that may be solved with numerical approaches, but this is computationally costly as the processes grow in complexity. In a new approach, dynamical processes are modelled with closed-form continuous-depth artificial neural networks. Improved efficiency in training and inference is demonstrated on various sequence modelling tasks including human action recognition and steering in autonomous driving.

    • Ramin Hasani
    • Mathias Lechner
    • Daniela Rus
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 4, P: 992-1003
  • Chemical proteomics profiling of 1,183 kinase inhibitors from past drug discovery projects revealed a large number of reasonably selective compounds for several kinases such as SYK and CK2.

    • Maria Reinecke
    • Paul Brear
    • Bernhard Kuster
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 577-585