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Showing 1–2 of 2 results
Advanced filters: Author: Mathieu Angin Clear advanced filters

  • Spontaneous control of HIV is linked to the ability of CD8+ T cells to eliminate infected CD4+ T cells. Here, the authors uncover metabolic differences between HIV-specific, central memory CD8+ T cells from spontaneous HIV controllers and antiretrovirally treated non-controllers, and show that in vitro metabolic reprogramming enhances the antiviral response in non-controllers cells.

    • Mathieu Angin
    • Stevenn Volant
    • Asier Sáez-Cirión
    Research
    Nature Metabolism
    Volume: 1, P: 704-716

  • T cell immunoglobulin and mucin domain–containing 3 (Tim-3) is an inhibitory receptor that is expressed on exhausted T cells and suppresses T helper type 1 (TH1) responses. Vijay Kuchroo and his colleagues show that human leukocyte antigen B (HLA-B)-associated transcript 3 (Bat3) binds intracellularly to Tim-3 and represses its function. Bat3 knockdown suppresses the development of experimental autoimmune encephalomyelitis and induces an exhaustion-like phenotype in T cells.

    • Manu Rangachari
    • Chen Zhu
    • Vijay K Kuchroo
    Research
    Nature Medicine
    Volume: 18, P: 1394-1400