Timothy Bestor and colleagues disrupt the Fbxl10 gene in mice, which leads to dense de novo DNA methylation of promoters that are co-occupied by both FBXL10 and by Polycomb repressive complexes. They conclude that FBXL10 protects Polycomb-bound genes from hypermethylation.
- Mathieu Boulard
- John R Edwards
- Timothy H Bestor
