PPP1R2, also known as Inhibitor-2, is a regulator of PP1 with an elusive function. Here, the authors show that PPP1R2 functions as an additional subunit of a subset of PP1 holoenzymes, thereby promoting the dephosphorylation of their substrates through stabilization of subunit interactions.
- Sarah Lemaire
- Mónica Ferreira
- Mathieu Bollen
