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Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database

Multiple drugs have been in the past associated with myocarditis. Here the authors perform a pharmacovigilance study and analyze 5108 reports of drug-induced myocarditis reporting temporal trends and overall mortality and identifying emerging drug classes among the treatments associated with myocarditis.

Lee S. Nguyen
Leslie T. Cooper
Joe-Elie Salem
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-10
Combinatorial, additive and dose-dependent drug–microbiome associations

An analysis of 2,173 individuals from the MetaCardis cohort quantifies the individual and combinatorial effects of a range of drugs on host health, metabolome and gut microbiome in cardiometabolic disease.

Sofia K. Forslund
Rima Chakaroun
Peer Bork
Research08 Dec 2021
Nature

Volume: 600, P: 500-505
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

A cross-sectional analysis of participants in the MetaCardis Body Mass Index Spectrum cohort finds that the higher prevalence of gut microbiota dysbiosis in individuals with obesity is not observed in those who take statin drugs.

Sara Vieira-Silva
Gwen Falony
Jeroen Raes
Research06 May 2020
Nature

Volume: 581, P: 310-315
Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
Amendments and CorrectionsOpen Access21 Dec 2020
Nature Communications

Volume: 11, P: 1
sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial

David M. Smadja
Clément R. Massonnaud
Benjamin Leveau
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-16
ST-segment elevation myocardial infarction

ST-segment elevation myocardial infarction (STEMI) is an acute coronary syndrome in which transmural ischaemia (mostly caused by the formation of a thrombus on a ruptured atherosclerotic plaque) leads to cardiomyocyte death. STEMI is associated with considerable morbidity and mortality worldwide.

Birgit Vogel
Bimmer E. Claessen
Roxana Mehran
Reviews06 Jun 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-20

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Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database

Combinatorial, additive and dose-dependent drug–microbiome associations

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial

ST-segment elevation myocardial infarction

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