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Showing 1–4 of 4 results
Advanced filters: Author: Mathieu Lafourcade Clear advanced filters

  • Lafourcade et al. find that a lifelong insufficiency in dietary n-3 polyunsaturated fatty acids leads to a specific loss of long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens in mice. This was associated with impaired emotional behavior.

    • Mathieu Lafourcade
    • Thomas Larrieu
    • Olivier J Manzoni
    Research
    Nature Neuroscience
    Volume: 14, P: 345-350

  • The authors define a specific cortical subregion of the somatosensory cortex as a critical region of dysfunction that is causal to the emergence of abnormal social and repetitive behaviours in mice exposed to maternal inflammation.

    • Yeong Shin Yim
    • Ashley Park
    • Gloria B. Choi
    Research
    Nature
    Volume: 549, P: 482-487

  • The authors report that, in the extended amygdala, 2-arachidonoylglycerol and anandamide mediate retrograde short-term depression and long-term depression, respectively, via different signaling pathways. In contrast, in the striatum, 2-arachidonoylglycerol and cannabinoid receptor 1–mediated retrograde signaling mediated both forms of plasticity.

    • Nagore Puente
    • Yihui Cui
    • Olivier J Manzoni
    Research
    Nature Neuroscience
    Volume: 14, P: 1542-1547

  • Marrs et al. show that the serine hydrolase α/β-hydrolase domain 6 (ABHD6) controls the accumulation and efficacy of the endocannabinoid 2-arachidonoylglycerol at cannabinoid receptors. ABHD6 is located post-synaptically and its selective inhibition permits the induction of cannabinoid receptor–dependent long-term depression by otherwise subthreshold stimulations.

    • William R Marrs
    • Jacqueline L Blankman
    • Nephi Stella
    Research
    Nature Neuroscience
    Volume: 13, P: 951-957