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miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Neurons make homeostatic adjustments to the strength of their synapses on the basis of their activity levels. Here the authors show the microRNA miR-92a represses the translation of the AMPA receptor subunit GluA1 and that, during activity blockade, its levels are reduced to increase the incorporation of new AMPA receptors.

Mathieu Letellier
Sara Elramah
Alexandre Favereaux
Research13 Jul 2014
Nature Neuroscience

Volume: 17, P: 1040-1042
Correction: Corrigendum: miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Mathieu Letellier
Sara Elramah
Alexandre Favereaux
Amendments and Corrections21 Nov 2014
Nature Neuroscience

Volume: 17, P: 1841
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface

Synapse nanocolumns control neural transmission through precise alignment of neurotransmitter receptors and release sites. Here, the authors identify the Neurexin-LRRTM2 complex as a central organiser of excitatory synapse nanostructure and function.

Konstantina Liouta
Malgorzata Lubas
Ingrid Chamma
ResearchOpen Access11 Oct 2024
Nature Communications

Volume: 15, P: 1-18
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation

Neuroligins are postsynaptic cell adhesion molecules thought to play roles in synaptic development and function. Here, authors show that phosphorylation of Y782 in neuroligin-1 modulates its role in differentiation and ability to recruit AMPARs including during long-term potentiation.

Mathieu Letellier
Zsófia Szíber
Olivier Thoumine
ResearchOpen Access28 Sept 2018
Nature Communications

Volume: 9, P: 1-17
Differential control of presynaptic efficacy by postsynaptic N-cadherin and β-catenin

In cultured hippocampal neurons, the authors show that postsynaptic N-cadherin is important to control the basal release probability, and that β-catenin acts via a different trans-synaptic pathway to control the gain adjustment of release probability.

Nathalia Vitureira
Mathieu Letellier
Yukiko Goda
Research04 Dec 2011
Nature Neuroscience

Volume: 15, P: 81-89
Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin

The advent of fluorescence-based super-resolution microscopy has created a need for labeling strategies relying on small probes that minimally perturb protein function. Here the authors describe a labeling method that reduces protein tag and label sizes, allowing for accurate protein targeting and measurements of protein dynamics in tight cellular spaces.

Ingrid Chamma
Mathieu Letellier
Olivier Thoumine
ResearchOpen Access16 Mar 2016
Nature Communications

Volume: 7, P: 1-15
Auto-Segmentation via deep-learning approaches for the assessment of flap volume after reconstructive surgery or radiotherapy in head and neck cancer

Juliette Thariat
Zacharia Mesbah
Romain Modzelewski
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
GRID1/GluD1 homozygous variants linked to intellectual disability and spastic paraplegia impair mGlu1/5 receptor signaling and excitatory synapses

Dévina C. Ung
Nicolas Pietrancosta
Frédéric Laumonnier
ResearchOpen Access28 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1205-1215

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miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Correction: Corrigendum: miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface

A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation

Differential control of presynaptic efficacy by postsynaptic N-cadherin and β-catenin

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin

Auto-Segmentation via deep-learning approaches for the assessment of flap volume after reconstructive surgery or radiotherapy in head and neck cancer

GRID1/GluD1 homozygous variants linked to intellectual disability and spastic paraplegia impair mGlu1/5 receptor signaling and excitatory synapses

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