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Advanced filters: Author: Mathieu Pecqueux Clear advanced filters

Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Scolaro et al. identify the enzyme cytidine deaminase (CDA) as upregulated in immunotherapy-resistant tumors and find it contributes to the UDP pool, which in turn modulates tumor-associated macrophages to instruct an immune-evasive TME.

Tommaso Scolaro
Marta Manco
Massimiliano Mazzone
ResearchOpen Access06 Jun 2024
Nature Cancer

Volume: 5, P: 1206-1226
Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration

Fang Cheng Wong
Sebastian R. Merker
Christoph Kahlert
ResearchOpen Access25 Jan 2025
British Journal of Cancer

Volume: 132, P: 326-339

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Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration

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