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Showing 1–2 of 2 results
Advanced filters: Author: Mathieu Quesnel-Vallières Clear advanced filters

  • Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify single point mutations and RNA-binding proteins that can control CD19 splicing and be associated with CD19 CAR-T therapy resistance.

    • Mariela Cortés-López
    • Laura Schulz
    • Julian König
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Transcriptome profiling in different brain regions has revealed distinct patterns of gene and non-coding RNA expression, as well as alternative splicing, in autism spectrum disorder (ASD). The authors review these ASD-associated signatures and the resulting mechanistic insights into ASD.

    • Mathieu Quesnel-Vallières
    • Robert J. Weatheritt
    • Benjamin J. Blencowe
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 51-63