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Showing 1–5 of 5 results
Advanced filters: Author: Mathilde Dusseaux Clear advanced filters

  • XCR1+ type 1 conventional DCs (cDC1s) are crucial to mount anti-tumor immune responses, however their infiltration within tumours is often limited. Here the authors show that cDC1 infiltration could be expanded by intratumoral delivery of mesenchymal stromal cells engineered to express the membrane bound form of FLT3L in combination with poly(I:C) or CXCL9 and CCL5, improving anti-tumor immunity in preclinical models.

    • Louise Gorline
    • Fillipe Luiz Rosa do Carmo
    • Pierre Guermonprez
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-22

  • Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • Shipra Das
    • Julien Valton
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Humanized mouse models are useful for studies of human hematopoiesis and immunity. Li et al. report an improved model that harbors lymph nodes and therefore permits investigation of local human adaptive immune processes in secondary lymphoid tissue.

    • Yan Li
    • Guillemette Masse-Ranson
    • James P. Di Santo
    Research
    Nature Methods
    Volume: 15, P: 623-630

  • Mucosal-associated invariant T cells are evolutionarily conserved innate lymphocytes whose physiological function has remained unclear. Lantz and colleagues now demonstrate an important antimicrobial function for these cells.

    • Lionel Le Bourhis
    • Emmanuel Martin
    • Olivier Lantz
    Research
    Nature Immunology
    Volume: 11, P: 701-708