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Showing 1–4 of 4 results
Advanced filters: Author: Mathilde Poulet Clear advanced filters

  • A study provides evidence for a shared lymphatic circuit that connects the posterior eye and the brain, allowing the generation of immune responses to protect the CNS against pathogens and tumours following intravitreal immunization.

    • Xiangyun Yin
    • Sophia Zhang
    • Eric Song
    ResearchOpen Access
    Nature
    Volume: 628, P: 204-211

  • The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.

    • Kevin Boyé
    • Luiz Henrique Geraldo
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • During blood vessel development, endothelial cells become specified toward arterial or venous fates. Chavkin et al find that distinct endothelial cell cycle states provide windows of opportunity for the molecular induction of arterial or venous fate.

    • Nicholas W. Chavkin
    • Gael Genet
    • Karen K. Hirschi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Poulet et al investigate the role for the PRL-2 phosphatase in mouse retina, and find that loss of PRL-2 impairs vascular outgrowth and arteriovenous patterning. They find that PRL-2 s regulates endothelial cell migration and sprouting angiogenesis and acts through VEGF and NOTCH1 signalling.

    • Mathilde Poulet
    • Jacinthe Sirois
    • Andreas Bikfalvi
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14