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Showing 1–5 of 5 results
Advanced filters: Author: Matilde Grasa Clear advanced filters

  • Basal cell carcinoma is a common cancer among people of European ancestry, with associated high economic costs to monitor and treat. Here Stacey et al.conduct a genome-wide association study on Icelandic and other European populations, identifying four novel loci associated with cancer susceptibility.

    • Simon N. Stacey
    • Hannes Helgason
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Simon Stacey and colleagues report several new susceptibility variants for basal cell carcinoma, including coding variants in KRT5, a variant at 9p21 near CDKN2A and CDKN2B and a variant at 7q32 near KLF14. The latter is an imprinted gene, and the effect at this locus is dependent on the parental origin of the risk allele.

    • Simon N Stacey
    • Patrick Sulem
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 41, P: 909-914

  • Gudbjartsson et al. report that variants near two genes, ASIP and TYR, are associated with risk of cutaneous melanoma and basal cell carcinoma. These loci are among several loci initially discovered for their role in human pigmentation, as reported by Sulem et al. In a separate study, Brown et al. independently discover an association between variants near ASIP and melanoma risk.

    • Daniel F Gudbjartsson
    • Patrick Sulem
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 40, P: 886-891