Nature Search

Predicting firearm suicide among US Army veterans transitioning from active service

This research developed and compared firearm-specific and method-agnostic machine-learning models using data from 800,579 Army veterans, revealing that model choice and intervention thresholds impact predictive accuracy and fairness, guiding tailored suicide prevention efforts.

Claire Houtsma
Chris J. Kennedy
Ronald C. Kessler
Research31 Dec 2025
Nature Mental Health

Volume: 4, P: 125-135
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

Ahyeon Hwang
Mario Skarica
Matthew J. Girgenti
ResearchOpen Access18 Jun 2025
Nature

Volume: 643, P: 744-754
Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

The chaperone SurA is involved in outer membrane protein (OMP) biogenesis in Gram-negative bacteria, but its mechanism of action is not fully understood. Combining mass spectrometric, biophysical and computational approaches, the authors here show how the conformational dynamics of SurA facilitate OMP binding.

Antonio N. Calabrese
Bob Schiffrin
Sheena E. Radford
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-16
Globally invariant metabolism but density-diversity mismatch in springtails

Springtails are omnipresent soil arthropods, vital for ecosystems. In the first global assessment of springtails, this study shows a 20-fold biomass difference between the tundra and the tropics, with distinct temperature-related patterns for diversity and metabolism that suggest climate change may restructure the functioning of soil biodiversity.

Anton M. Potapov
Carlos A. Guerra
Stefan Scheu
ResearchOpen Access07 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Anti-tumor efficacy of a potent and selective non-covalent KRAS^G12D inhibitor

A potent and selective inhibitor of KRAS^G12D, the most common mutant form of the KRAS oncoprotein, has anti-tumor efficacy in multiple pre-clinical cancer models, opening the possibility to therapeutically target this highly prevalent oncogenic driver.

Jill Hallin
Vickie Bowcut
James G. Christensen
Research10 Oct 2022
Nature Medicine

Volume: 28, P: 2171-2182
A general strategy for expanding polymerase function by droplet microfluidics

Droplet-based optical polymerase sorting employs a fluorescent sensor to monitor polymerase activity inside the microenvironment of uniform water-in-oil emulsions. Here, the authors use this technique to select and isolate single cells for evolution of an unnatural nucleic acid polymerase.

Andrew C. Larsen
Matthew R. Dunn
John C. Chaput
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-9
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

Opioid use disorder (OUD) is influenced by genetic and environmental factors. Here, authors use a multi-omics approach to reveal DNA hydroxymethylation as an important gene regulatory mechanism for OUD in the human brain.

Gregory Rompala
Sheila T. Nagamatsu
Janitza L. Montalvo-Ortiz
ResearchOpen Access28 Jul 2023
Nature Communications

Volume: 14, P: 1-14
Transcriptomic organization of the human brain in post-traumatic stress disorder

A transcriptome-wide characterization of the molecular pathology of post-traumatic stress disorder (PTSD) postmortem brains provides a comprehensive resource for mechanistic insight and therapeutic development.

Matthew J. Girgenti
Jiawei Wang
Ronald S. Duman
Research21 Dec 2020
Nature Neuroscience

Volume: 24, P: 24-33
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

A multi-ancestry transcriptome-wide association study using an optimal linear combination of association statistics provides insights into tobacco use biology and suggests opportunities for drug repurposing.

Fang Chen
Xingyan Wang
Dajiang J. Liu
ResearchOpen Access26 Jan 2023
Nature Genetics

Volume: 55, P: 291-300
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.

Marcel A. Dammert
Johannes Brägelmann
Martin L. Sos
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-11
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

Here the authors reveal that a neomorphic mutation in chromatin protein SMCHD1 enhances SMCHD1-mediated gene silencing, including at the FSHD disease-relevant locus, while depleting SMCHD1-mediated chromatin interactions, suggesting these SMCHD1 functions are unlinked.

Andres Tapia del Fierro
Bianca den Hamer
Marnie E. Blewitt
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-22
SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings

Air surveillance offers a potential means of monitoring airborne pathogens without the need for individual sampling. Here, the authors perform continuous air sampling in 15 community settings in the US for 29 weeks and demonstrate its feasibility for routine detection of SARS-CoV-2 and other respiratory pathogens.

Mitchell D. Ramuta
Christina M. Newman
Shelby L. O’Connor
ResearchOpen Access11 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Global supernatural beliefs

Supernatural beliefs shape how people understand the world, but there is debate regarding how these beliefs relate to the natural or social world. Jackson and colleagues quantitatively analysed the ethnographic record and found evidence that supernatural explanations are more commonly used for natural than for social phenomena.

Matthew I. Billet
Ara Norenzayan
News & Views03 Apr 2023
Nature Human Behaviour

Volume: 7, P: 670-671
Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans

Janitza L. Montalvo-Ortiz
Joel Gelernter
Robert H. Pietrzak
ResearchOpen Access17 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-9
Transitioning metal–organic frameworks from the laboratory to market through applied research

Metal–organic frameworks are a class of materials that have attracted researchers for over 25 years and have been proposed for many applications. This Perspective discusses critical topics in applied research for commercialization, and highlights challenges associated with product development.

Ashley M. Wright
Matthew T. Kapelewski
William Morris
Reviews08 Aug 2024
Nature Materials

Volume: 24, P: 178-187
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling

Proteomics, lipidomics and metabolomics of single gene deletion yeast strains sheds light on mitochondrial protein biology.

Jonathan A Stefely
Nicholas W Kwiecien
Joshua J Coon
Research26 Sept 2016
Nature Biotechnology

Volume: 34, P: 1191-1197
Global fine-resolution data on springtail abundance and community structure

Anton M. Potapov
Ting-Wen Chen
Stefan Scheu
ResearchOpen Access03 Jan 2024
Scientific Data

Volume: 11, P: 1-14
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

Search

Predicting firearm suicide among US Army veterans transitioning from active service

Mapping the human genetic architecture of COVID-19

A second update on mapping the human genetic architecture of COVID-19

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

Globally invariant metabolism but density-diversity mismatch in springtails

Anti-tumor efficacy of a potent and selective non-covalent KRAS^G12D inhibitor

A general strategy for expanding polymerase function by droplet microfluidics

Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

Transcriptomic organization of the human brain in post-traumatic stress disorder

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

One thousand plant transcriptomes and the phylogenomics of green plants

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings

Global supernatural beliefs

Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans

Transitioning metal–organic frameworks from the laboratory to market through applied research

AI is a viable alternative to high throughput screening: a 318-target study

Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling

Global fine-resolution data on springtail abundance and community structure

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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