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Showing 1–4 of 4 results
Advanced filters: Author: Matthew Axtman Clear advanced filters

  • Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inhibitors of fatty acid biosynthesis in bacteria.

    • Katherine A. Abrahams
    • Chun-wa Chung
    • Robert H. Bates
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

    • Aled M. Edwards
    • Dafydd R. Owen
    • Suzanne Ackloo
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 634-645