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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.

Matthew L. Kutys
William J. Polacheck
Christopher S. Chen
ResearchOpen Access06 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Chen et al. show that subtypes of immune cells in prenatal human brain promote angiogenesis in the germinal matrix. Conversely, in preterm infants, proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage.

Jiapei Chen
Elizabeth E. Crouch
Eric J. Huang
ResearchOpen Access30 Sept 2024
Nature Neuroscience

Volume: 27, P: 2115-2129
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling

Kwak et al. report that adherens junctions organize membrane microdomains, leading to lipid-dependent γ-secretase recruitment and size-dependent protein segregation, excluding full-length Notch receptor.

Minsuk Kwak
Kaden M. Southard
Young-wook Jun
Research01 Dec 2022
Nature Cell Biology

Volume: 24, P: 1739-1753
A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

The link between stiffness heterogeneity and tumor cell heterogeneity remains poorly understood. Here, authors propose an AI-informed method that reveals correlations between stromal stiffness and breast cancer cells with a heterogeneous EMT phenotype.

Connor Stashko
Mary-Kate Hayward
Valerie M. Weaver
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-16
A non-canonical Notch complex regulates adherens junctions and vascular barrier function

The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.

William J. Polacheck
Matthew L. Kutys
Christopher S. Chen
Research13 Nov 2017
Nature

Volume: 552, P: 258-262
An extracellular-matrix-specific GEF–GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration

Yamada and colleagues report that the interaction of the β-Pix guanine exchange nucleotide factor with the GTPase activating protein, srGAP1, regulates cell migration through collagen by activating Cdc42 and suppressing RhoA activity.

Matthew L. Kutys
Kenneth M. Yamada
Research24 Aug 2014
Nature Cell Biology

Volume: 16, P: 909-917
Microfabricated blood vessels for modeling the vascular transport barrier

Cells are seeded into an extracellular matrix template and flow is applied to create microfabricated blood vessels.

William J. Polacheck
Matthew L. Kutys
Christopher S. Chen
Protocols05 Apr 2019
Nature Protocols

Volume: 14, P: 1425-1454

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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

An extracellular-matrix-specific GEF–GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration

Microfabricated blood vessels for modeling the vascular transport barrier

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