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Showing 1–4 of 4 results

Advanced filters: Author: Matthew N Svalina Clear advanced filters

Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma

Almer et al. conduct a 3D computational model of the drug dispersion and validate biological responses with microfluidic studies. The compound utilized, IGF1R inhibitor BMS875807, could reach tumors and help stop new tumors, but not regress established metastasis.

Alyssa G. Almer
Samuel V. Rasmussen
Charles Keller
ResearchOpen Access28 May 2025
Communications Medicine

Volume: 5, P: 1-11
Erratum: Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S Grasso
Yujie Tang
Michelle Monje
Amendments and Corrections07 Jul 2015
Nature Medicine

Volume: 21, P: 827
IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma

Matthew N. Svalina
Ken Kikuchi
Charles Keller
ResearchOpen Access03 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

The study describes the use of integrative approaches to search for candidate therapeutic targets for DIPG, and the identification of an HDAC inhibitor as a potential treatment strategy

Catherine S Grasso
Yujie Tang
Michelle Monje
Research04 May 2015
Nature Medicine

Volume: 21, P: 555-559