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Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step

Taylor J. B. Forrester
Olga G. Ovchinnikova
Matthew S. Kimber
Amendments and CorrectionsOpen Access12 Dec 2022
Nature Communications

Volume: 13, P: 1
The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step

WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor. Therefore, unlike any previously studied glycosyltransferase, WbbB uses the double-displacement mechanism first proposed in 1953.

Taylor J. B. Forrester
Olga G. Ovchinnikova
Matthew S. Kimber
ResearchOpen Access21 Oct 2022
Nature Communications

Volume: 13, P: 1-13
The biosynthetic origin of ribofuranose in bacterial polysaccharides

Ribofuranose residues are installed on O-antigens of bacterial polysaccharides by a dual-activity enzyme that uses phosphoribosyl-5-phospho-d-ribosyl-α-1-diphosphate as a sugar donor and also catalyzes phosphate hydrolysis.

Steven D. Kelly
Danielle M. Williams
Chris Whitfield
Research07 Apr 2022
Nature Chemical Biology

Volume: 18, P: 530-537
Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules

Reconstitution of β-Kdo-based capsular polysaccharide biosynthesis and crystallographic analysis of KpsC, a glycosyltransferase with two active sites for β-Kdo-glycolipid primer extension, reveal a new glycosyltransferase structural family.

Liam Doyle
Olga G. Ovchinnikova
Chris Whitfield
Research29 Apr 2019
Nature Chemical Biology

Volume: 15, P: 632-640
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family

Structural characterization of WbbM, an enzyme involved in O2a-antigen biosynthesis in Klebsiella pneumoniae, reveals two unique active sites with galactopyranosyl- or galactofuranosyl-transferase activities for oligosaccharide polymerization.

Bradley R. Clarke
Olga G. Ovchinnikova
Chris Whitfield
Research09 Mar 2020
Nature Chemical Biology

Volume: 16, P: 450-457
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting associated with unfavourable outcomes during pregnancy. Here, Fejzo et al. perform genome-wide scans for HG and pregnancy nausea and vomiting and identify genetic associations at two loci implicating the genes GDF15 and IGFBP7.

Marlena S. Fejzo
Olga V. Sazonova
Catherine H. Wilson
ResearchOpen Access21 Mar 2018
Nature Communications

Volume: 9, P: 1-9
The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis

Rosie Griffiths
Steven Woods
Susan J. Kimber
ResearchOpen Access16 Mar 2020
Scientific Reports

Volume: 10, P: 1-16
Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry

Kaveh Rayani
Brianna Davies
Zachary W. M. Laksman
Research22 Sept 2022
European Journal of Human Genetics

Volume: 31, P: 512-520
Structure–function characterization of an aldo–keto reductase involved in detoxification of the mycotoxin, deoxynivalenol

Nadine Abraham
Kurt L. Schroeter
Stephen Y. K. Seah
ResearchOpen Access30 Aug 2022
Scientific Reports

Volume: 12, P: 1-13
A processive endoglucanase with multi-substrate specificity is characterized from porcine gut microbiota

Weijun Wang
Tania Archbold
Ming Z. Fan
ResearchOpen Access20 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

Angela H. Guo
Rachael Baliira
David B. Lombard
ResearchOpen Access18 Jul 2022
Scientific Reports

Volume: 12, P: 1-14

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Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step

The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step

The biosynthetic origin of ribofuranose in bacterial polysaccharides

Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules

A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis

Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry

Structure–function characterization of an aldo–keto reductase involved in detoxification of the mycotoxin, deoxynivalenol

A processive endoglucanase with multi-substrate specificity is characterized from porcine gut microbiota

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

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