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Showing 1–8 of 8 results
Advanced filters: Author: Matthew S. Rodeheffer Clear advanced filters

  • During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.

    • Rachel K. Zwick
    • Michael C. Rudolph
    • Valerie Horsley
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Rodeheffer and colleagues show that a high-fat diet in mice activates Akt2 signalling in adipocyte precursors within white adipose tissue deposits, leading to their proliferation and differentiation into adipocytes, and to obesity.

    • Elise Jeffery
    • Christopher D. Church
    • Matthew S. Rodeheffer
    Research
    Nature Cell Biology
    Volume: 17, P: 376-385

  • Adipocytes have been suggested to arise from prospective progenitors of endothelial or haematopoietic origin. Rödeheffer and colleagues use lineage tracing to rule out that this is the case for white adipocytes, and show that they instead arise from CD24+ cells that are characterized by the expression of PdgfR (platelet-derived growth factor receptor).

    • Ryan Berry
    • Matthew S. Rodeheffer
    Research
    Nature Cell Biology
    Volume: 15, P: 302-308

  • Using a database of doubly labelled water energy expenditure measurements spanning more than 30 years, Speakman and colleagues show that total energy expenditure in humans has declined over time, while adjusted physical activity energy expenditure has increased over time.

    • John R. Speakman
    • Jasper M. A. de Jong
    • William W. Wong
    Research
    Nature Metabolism
    Volume: 5, P: 579-588

  • Adipocytes and scar tissue form during skeletal muscle degeneration. Two new studies reveal that adipocytes and fibroblasts in skeletal muscle derive from a population of bipotent progenitors that reside within muscle, but are not derived from the muscle lineage. These progenitor cells also have a surprising role in stimulating the restoration of muscle mass during regeneration.

    • Matthew S. Rodeheffer
    News & Views
    Nature Cell Biology
    Volume: 12, P: 102-104

  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19