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Showing 1–5 of 5 results
Advanced filters: Author: Matthew S. Waitkus Clear advanced filters

  • Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERTpWT-IDHWT glioblastoma). Here, the authors present a genetic landscape of TERTpWT-IDHWT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.

    • Bill H. Diplas
    • Xujun He
    • Hai Yan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • ATRX inactivation occurs often in IDH-mutant gliomas and has been associated with immune dysfunction. Here, using preclinical models of glioma, the authors show that ATRX inactivation promotes innate immune signalling in response to double stranded RNA-based innate immune agonists, an effect that is masked in IDH-mutant tumours, presenting a therapeutic vulnerability.

    • Seethalakshmi Hariharan
    • Benjamin T. Whitfield
    • David M. Ashley
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical profiles.

    • Lee H. Chen
    • Changcun Pan
    • Liwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The development of METIS: a computational approach to identify cancer mutations that confer novel catalytic functions upon enzymes, then apply these mutations towards green chemistry or therapeutic development.

    • Kevin J. Tu
    • Bill H. Diplas
    • Zachary J. Reitman
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-11