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Showing 1–26 of 26 results
Advanced filters: Author: Matthew Sigman Clear advanced filters
  • A workflow for deriving statistical models of one set of reactions that can be used to predict related reactions is presented, facilitating catalyst and enantioselective reaction development.

    • Jolene P. Reid
    • Matthew S. Sigman
    Research
    Nature
    Volume: 571, P: 343-348
  • A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group.

    • Tian-Sheng Mei
    • Harshkumar H. Patel
    • Matthew S. Sigman
    Research
    Nature
    Volume: 508, P: 340-344
  • Biomolecular condensates compartmentalize molecules without membranes. Understanding condensate composition is important given that their function relies on the selective exclusion or enrichment of molecules. Now, investigating small-molecule partitioning reveals variations across compounds, yet correlations indicate physical similarities between disparate condensates. Machine learning accurately predicts partitioning on the basis of physicochemical features, demonstrating the role of a hydrophobic environment in driving enrichment and exclusion.

    • Sabareesan Ambadi Thody
    • Hanna D. Clements
    • Michael K. Rosen
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1794-1802
  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

    • Harry Pickering
    • Joanna Schaenman
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Southern Ocean surface waters near Australia emerged as a major source of CO2 during the last deglaciation due to shifting ecology and circulation, according a proxy record of seawater pH based on boron isotopes covering the past 25,000 years.

    • Andrew D. Moy
    • Martin R. Palmer
    • Thomas B. Chalk
    Research
    Nature Geoscience
    Volume: 12, P: 1006-1011
  • Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

    • Al Ozonoff
    • Naresh Doni Jayavelu
    • Nadine Rouphael
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Multivariate linear regression methods have become useful predictive tools that can complement potentially computationally expensive and complex transition state calculations. This Review compares these methods, highlights the advantages of each and identifies challenges for the future.

    • Jolene P. Reid
    • Matthew S. Sigman
    Reviews
    Nature Reviews Chemistry
    Volume: 2, P: 290-305
  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • A perspective is given on how an electrocatalytic approach, inspired by decades of energy storage studies, can be used in the context of efficient cobalt-hydride generation with a variety of applications in modern organic synthesis.

    • Samer Gnaim
    • Adriano Bauer
    • Phil S. Baran
    Research
    Nature
    Volume: 605, P: 687-695
  • Electrochemical research often requires stringent combinations of experimental parameters that are demanding to manually locate. Here the authors report an autonomous electrochemical platform that implements an adaptive, closed-loop workflow for mechanistic investigation of molecular electrochemistry.

    • Hongyuan Sheng
    • Jingwen Sun
    • Chong Liu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Many parameters have been designed to describe steric size, but few have been able to explain consistently the selectivity of asymmetric catalytic reactions. Here, Sterimol parameters — originally used to develop quantitative structure–activity relationships in medicinal chemistry — have been used to quantify enantioselectivity in a diverse collection of asymmetric catalytic reactions.

    • Kaid C. Harper
    • Elizabeth N. Bess
    • Matthew S. Sigman
    Research
    Nature Chemistry
    Volume: 4, P: 366-374
  • The choice of ligand used in a reaction can drastically influence the overall outcome. Using a combination of classic physical organic chemistry and modern mathematical modelling, phosphine ligand effects are probed. The methods described provide the groundwork for future mechanistic studies of this ubiquitous ligand class.

    • Zachary L. Niemeyer
    • Anat Milo
    • Matthew S. Sigman
    Research
    Nature Chemistry
    Volume: 8, P: 610-617
  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Although methods exist to construct secondary stereocentres containing both a C–F and C–H bond, the ability to form a tertiary C–F bond, remote from pre-existing activating groups, remains challenging. Now, C–F tertiary, benzylic stereocentres have been constructed through a Pd-catalysed enantioselective Heck reaction of acyclic alkenyl fluorides with arylboronic acids.

    • Jianbo Liu
    • Qianjia Yuan
    • Matthew S. Sigman
    Research
    Nature Chemistry
    Volume: 11, P: 710-715
  • Our increasing understanding of non-covalent interactions involving aromatic systems is reviewed, and the use of these insights in the design of small-molecule catalysts and enzymes is surveyed.

    • Andrew J. Neel
    • Margaret J. Hilton
    • F. Dean Toste
    Reviews
    Nature
    Volume: 543, P: 637-646
  • Patients with mild COVID-19 show a pattern of interferon-stimulated gene (ISG) expression across all major cell types, but in patients with severe disease, antibodies block the production of these ISG-expressing cells.

    • Alexis J. Combes
    • Tristan Courau
    • Matthew F. Krummel
    Research
    Nature
    Volume: 591, P: 124-130
  • Although structural variation has been previously associated with autism spectrum disorders, this study reports a genome-wide significant association of common variants with susceptibility to this disorder group. The results implicate neuronal cell-adhesion molecules in the pathogenesis of this group of neurodevelopmental and neuropsychiatric disorders.

    • Kai Wang
    • Haitao Zhang
    • Hakon Hakonarson
    Research
    Nature
    Volume: 459, P: 528-533
  • A set of parameters based on the response of a molecule’s properties to infrared vibrations can be used to model and predict selectivity trends for molecular reactions with interlinked steric and electronic effects at positions of interest

    • Anat Milo
    • Elizabeth N. Bess
    • Matthew S. Sigman
    Research
    Nature
    Volume: 507, P: 210-214
  • In enzyme-catalysed metabolic pathways, substrate channelling often directs the movement of intermediates from one active site to the next. Intramolecular tunnels, electrostatic interactions and chemical swing arms pass intermediates from one enzyme to the next, enhancing pathway catalysis. Introducing mechanisms of bounded diffusion in chemical cascades can increase selectivity, transient rates and overall yield.

    • Ian Wheeldon
    • Shelley D. Minteer
    • Matthew Sigman
    Reviews
    Nature Chemistry
    Volume: 8, P: 299-309
  • An automated closed-loop system optimizes a stereoselective Suzuki-Miyaura reaction using a machine learning algorithm that incorporates unbiased and categorical process parameters.

    • Melodie Christensen
    • Lars P. E. Yunker
    • Jason E. Hein
    ResearchOpen Access
    Communications Chemistry
    Volume: 4, P: 1-12
  • Between 28 and 100% of nitrogen fixation in the South Atlantic occurs within the Angola Gyre and is potentially fuelled by supply of bioavailable iron from margin sediments and excess phosphorus, according to an analysis of observational hydrographic data and nitrate isotope ratios.

    • Tanya Marshall
    • Julie Granger
    • Sarah E. Fawcett
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 3, P: 1-10