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Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa

Multidrug-resistant pathogens have become increasingly common in hospital settings. Here, the authors investigate the efficacy of adjunctive antibiotic and phage therapy in a human cell model and a murine model of ventilator-associated pneumonia.

Chantal Weissfuss
Jingjing Li
Geraldine Nouailles
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-17
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Here authors show that GDF15, a cytokine that is produced by cancer cells, prevents T cells from extravasation into the tumour microenvironment. Low availability of T cells in GDF-15-expressing tumours thus precludes effective immune therapy.

Markus Haake
Beatrice Haack
Jörg Wischhusen
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases

Konstantin Karmilin
Carlo Schmitz
Walter Stöcker
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-12