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Showing 1–8 of 8 results
Advanced filters: Author: Matthias Götte Clear advanced filters

  • X-ray crystallography, cryo-electron microscopy, structural modelling, biochemistry, cell biology, and evolutionary analysis enable characterization of ORF2p, the reverse transcriptase of the ancient ‘parasitic’ LINE-1 retrotransposon that has written around one-third of the human genome.

    • Eric T. Baldwin
    • Trevor van Eeuwen
    • Martin S. Taylor
    ResearchOpen Access
    Nature
    Volume: 626, P: 194-206

  • Treatment of HCV infection has evolved rapidly with the development of effective direct-acting antiviral agents (DAAs) that target different stages in the viral life cycle. Here, Götte and Feld describe the mechanisms of action of these DAAs and the different clinical attributes of each drug class (such as barriers to resistance, drug–drug interactions). Challenges in drug development efforts for the future are also briefly discussed.

    • Matthias Götte
    • Jordan J. Feld
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 338-351

  • Cryo-EM is used to visualize the SARS-CoV-2 RTC bound to each of the natural NTPs as well as remdesivir triphosphate (RDV-TP) in states poised for incorporation, explaining the interactions required for NTP recognition and RDV-TP selectivity.

    • Brandon F. Malone
    • Jason K. Perry
    • Seth A. Darst
    Research
    Nature
    Volume: 614, P: 781-787

  • Nucleic acid polymerases catalyze nucleotidyl transfer reactions with two proton-transfer events, deprotonation of the 3′-hydroxyl nucleophile and protonation of the pyrophosphate leaving group. Functional analyses now show that the proton donor for the latter transfer is an active-site residue.

    • Christian Castro
    • Eric D Smidansky
    • Craig E Cameron
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 212-218

  • Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.

    • Samer Girgis
    • Zaikun Xu
    • Jerry Pelletier
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12