A chronic inflammatory state, leading to local and systemic deleterious effects on host cells and tissues, is maintained in several diseases. Here, Gaestel and colleagues review current understanding of the roles and molecular mechanisms of kinase signalling in inflammation, emphasizing the most recent advances in the development of specific small-molecule kinase inhibitors for the treatment of chronic inflammation.
- Matthias Gaestel
- Alexey Kotlyarov
- Michael Kracht
