Morphogens direct cell fates across tissues through concentration gradients. Pentagone, a secreted protein and a newly identified target of the Drosophila bone morphogenetic protein decapentaplegic (Dpp), is shown to promote long-range distribution of the Dpp ligand in the wing through its binding to the heparan-sulphate proteoglycan Dally.
- Robin Vuilleumier
- Alexander Springhorn
- George Pyrowolakis
