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Showing 1–12 of 12 results
Advanced filters: Author: Matthias Kaschube Clear advanced filters

  • Sensory experience transforms endogenously structured cortical networks with diverse and unreliable visual responses into reliable representations. This process is proposed to involve the alignment of feedforward and recurrent networks.

    • Sigrid Trägenap
    • David E. Whitney
    • Matthias Kaschube
    Research
    Nature Neuroscience
    Volume: 28, P: 394-405

  • How the cortex forms spatially structured modules during development is poorly understood. Here, the authors show that activity in early developing cortex is self-organized though local-excitation and lateral inhibition.

    • Haleigh N. Mulholland
    • Matthias Kaschube
    • Gordon B. Smith
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Distributed networks in visual cortex precisely link the fine-scale functional architecture with distant network elements and appear early in development, when heterogeneous local connections may seed long-range network interactions.

    • Gordon B. Smith
    • Bettina Hein
    • Matthias Kaschube
    Research
    Nature Neuroscience
    Volume: 21, P: 1600-1608

  • This study investigates how homeostatic mechanisms endow sensory representations in the auditory cortex with resilience against neuron loss. The map of sounds has the ability to recover after microablation by recruiting previously unresponsive neurons.

    • Takahiro Noda
    • Eike Kienle
    • Simon Rumpel
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 1533-1545

  • Rapid developmental changes in the response properties of neurons in visual cortex enhance motion discriminability following eye opening. Here the authors show that increases in direction selectivity are accompanied by reductions in the density of active neurons and variability in their responses and levels of noise correlation, changes that depend on the nature of visual experience.

    • Gordon B Smith
    • Audrey Sederberg
    • David Fitzpatrick
    Research
    Nature Neuroscience
    Volume: 18, P: 252-261

  • During gastrulation in Drosophila embryo, there is apical constriction of ventral cells, which results in formation of a ventral furrow and invagination of the mesoderm. This study reports a mechanism for this process and shows that apical constriction of ventral cells is pulsed. These pulses are powered by the actin–myosin contractions and are dependent on the expression of a transcription factor, Snail, whereas the constricted state is stabilized by the transcription factor Twist.

    • Adam C. Martin
    • Matthias Kaschube
    • Eric F. Wieschaus
    Research
    Nature
    Volume: 457, P: 495-499