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Showing 1–4 of 4 results
Advanced filters: Author: Matthias Marschal Clear advanced filters
  • The nasal commensal bacterium Staphylococcus lugdunensis produces a novel cyclic peptide antibiotic, lugdunin, that inhibits colonization by S. aureus in animal models and is associated with a significantly reduced S. aureus carriage rate in humans, suggesting that human commensal bacteria could be a valuable resource for the discovery of new antibiotics.

    • Alexander Zipperer
    • Martin C. Konnerth
    • Bernhard Krismer
    Research
    Nature
    Volume: 535, P: 511-516
  • Chordomas are rare bone tumors with limited therapeutic options. Here, the authors identify molecular alterations associated with defective homologous recombination DNA repair in advanced chordomas and report prolonged response in a patient treated with a PARP inhibitor, which later acquired resistance due to a newly gained PARP1 mutation.

    • Stefan Gröschel
    • Daniel Hübschmann
    • Stefan Fröhling
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9
  • Horizontal gene transfer of mobile genetic elements contributes to bacterial evolution and emergence of new pathogens. Here the authors demonstrate that the highly diverse structure of wall teichoic acid polymers governs horizontal gene transfer among Gram-positive pathogens, even across long phylogenetic distances.

    • Volker Winstel
    • Chunguang Liang
    • Guoqing Xia
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-9