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Showing 1–3 of 3 results
Advanced filters: Author: Matthias Michalek Clear advanced filters

  • Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

    • Maximilian Zenk
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Acanthaporin is identified as a pore-forming protein from the infectious Acanthamoeba culbertsoni with a previously unknown structure. The newly identified structure includes a pH-dependent histidine switch that controls partitioning between the inactive dimer and the active monomer, which assembles into larger species to cause toxicity.

    • Matthias Michalek
    • Frank D Sönnichsen
    • Matthias Leippe
    Research
    Nature Chemical Biology
    Volume: 9, P: 37-42

  • ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.

    • Anselm Sommer
    • Felix Kordowski
    • Karina Reiss
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14