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Showing 1–10 of 10 results
Advanced filters: Author: Matthias Osswald Clear advanced filters

  • Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both niches can partially compensate for each other and that glioma cells localized in both niches are resistant to radio- and chemotherapy.

    • Erik Jung
    • Matthias Osswald
    • Frank Winkler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • A population of highly interconnected cells in glioblastoma makes these tumours resistant to general damage but vulnerable to targeted disruption of this small fraction of cells and their rhythmic Ca2+ oscillations.

    • David Hausmann
    • Dirk C. Hoffmann
    • Frank Winkler
    Research
    Nature
    Volume: 613, P: 179-186

  • Brain tumours are difficult to treat because of their propensity to infiltrate brain tissue; here long processes, or tumour microtubes, extended by astrocytomas are shown to promote brain infiltration and to create an interconnected network that enables multicellular communication and that protects the tumours from radiotherapy-induced cell death, suggesting that disruption of the network could be a new therapeutic approach.

    • Matthias Osswald
    • Erik Jung
    • Frank Winkler
    Research
    Nature
    Volume: 528, P: 93-98

  • Most DNA-encoded library (DEL) syntheses are limited by the presence of sensitive DNA-based constructs. Here, the authors develop DOSEDO, a diverse 3.7 million compound DEL, generated through diversity-oriented synthesis that provides enhanced scaffold and exit vector diversity and gives validated binding hits for multiple protein targets.

    • Liam Hudson
    • Jeremy W. Mason
    • Karin Briner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner.

    • Theresa Schumacher
    • Lukas Bunse
    • Michael Platten
    Research
    Nature
    Volume: 512, P: 324-327

  • Malignant gliomas recapitulate steps in neurodevelopment to form organ-like structures. Jung et al. review how neuroscience can provide novel insights into glioma biology, and how these insights might be used for future therapeutic approaches.

    • Erik Jung
    • Julieta Alfonso
    • Frank Winkler
    Reviews
    Nature Neuroscience
    Volume: 22, P: 1951-1960