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Showing 1–5 of 5 results
Advanced filters: Author: Matthieu Giraud Clear advanced filters

  • The human thymus is given the difficult task of teaching T-cells which antigens are 'foreign' and which are 'self', a process which seems to go wrong in autoimmune disorders. A study of variation in the promoter of one gene expressed in thymus shows that one nucleotide change can disrupt gene regulation, and might lead to increased risk for autoimmune disease.

    • Matthieu Giraud
    • Richard Taubert
    • Henri-Jean Garchon
    Research
    Nature
    Volume: 448, P: 934-937

  • Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional regulator Aire and is essential for Aire's ability to switch on the expression of tissue-specific genes.

    • Anna Chuprin
    • Ayelet Avin
    • Jakub Abramson
    Research
    Nature Immunology
    Volume: 16, P: 737-745

  • Abramson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions in the locus encoding the transcriptional regulator Aire to control its expression.

    • Yonatan Herzig
    • Shir Nevo
    • Jakub Abramson
    Research
    Nature Immunology
    Volume: 18, P: 161-172

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703