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Advanced filters: Author: Matthieu Lagardère Clear advanced filters

Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors

Histidine 73 methylation in β-actin modulates actin plasticity, affecting monomer dynamics and filament stability. Using molecular dynamics simulations, the study reveals that methylation influences nucleotide binding cleft opening and phosphate release.

Adrien Schahl
Louis Lagardère
Jean-Philip Piquemal
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration

Mehidi et al. show that piconewton forces exerted by the polymerization of individual actin filaments displace the WAVE regulatory complex from lamellipodial tips, thereby regulating WAVE complex activity during cell migration.

Amine Mehidi
Frieda Kage
Grégory Giannone
Research04 Nov 2021
Nature Cell Biology

Volume: 23, P: 1148-1162
FluoSim: simulator of single molecule dynamics for fluorescence live-cell and super-resolution imaging of membrane proteins

Matthieu Lagardère
Ingrid Chamma
Olivier Thoumine
ResearchOpen Access17 Nov 2020
Scientific Reports

Volume: 10, P: 1-14