Nature Search

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer

Deep whole-genome sequencing of serial blood samples and matched metastatic tissue reveals that circulating tumour DNA profiling enables detailed study of treatment-driven subclone dynamics, epigenomics and genome-wide somatic evolution in metastatic human cancers.

Cameron Herberts
Matti Annala
Alexander W. Wyatt
Research20 Jul 2022
Nature

Volume: 608, P: 199-208
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

SUMOylation is known to regulate androgen receptor (AR) activity in cultured cells. Here, using SUMOylation-deficient AR knock-in mice, the authors demonstrate that SUMOylation is required for AR-related gene expression specifically in the epididymal tissues, but not the testis.

Fu-Ping Zhang
Marjo Malinen
Jorma J. Palvimo
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Insulin Autoantibody Isotypes during the Prediabetic Process in Young Children with Increased Genetic Risk of Type 1 Diabetes

Sanna Hoppu
Matti S Ronkainen
Mikael Knip
Research01 Feb 2004
Pediatric Research

Volume: 55, P: 236-242
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

Shady Adnan Awad
Olli Dufva
Satu Mustjoki
ResearchOpen Access11 Aug 2020
Leukemia

Volume: 35, P: 1087-1099
Establishing a GMP-compliant manufacturing process and phase-appropriate analytics for early development of a FiCAR T-cell product with a novel CAR spacer

Annu Luostarinen
Arja Vuorela
Anita Laitinen
ResearchOpen Access08 Mar 2025
Scientific Reports

Volume: 15, P: 1-17
Measurement of the nucleation of atmospheric aerosol particles

Markku Kulmala
Tuukka Petäjä
Veli-Matti Kerminen
Protocols16 Aug 2012
Nature Protocols

Volume: 7, P: 1651-1667
Automated and closed clinical-grade manufacturing protocol produces potent NK cells against neuroblastoma cells and AML blasts

Farhana Jahan
Leena Penna
Erja Kerkelä
ResearchOpen Access04 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Association of body-mass index with physiological brain pulsations across adulthood – a fast fMRI study

Lauri Raitamaa
Joona Kautto
Vesa Kiviniemi
ResearchOpen Access29 Mar 2024
International Journal of Obesity

Volume: 48, P: 1011-1018
Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms

Seyed-Mohsen Ebrahimi
Johanna Tuunanen
Vesa Kiviniemi
ResearchOpen Access26 Jan 2024
Scientific Reports

Volume: 14, P: 1-17
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy

Järvelä et al. investigate if narcolepsy is associated with altered brain pulsations using ultrafast fMRI. They find differences in the brain pulsations between narcolepsy type 1 patients and healthy controls that may link to altered brain clearance in narcolepsy, have diagnostic potential and correlate with the severity of narcolepsy.

Matti Järvelä
Janne Kananen
Vesa Kiviniemi
ResearchOpen Access30 Sept 2022
Communications Medicine

Volume: 2, P: 1-13
Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent

Jadwiga Buchwald
Meghan J. Chenoweth
Rachel F. Tyndale
Research10 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2212-2223
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

Petri Pölönen
Ashik Jawahar Deen
Anna-Liisa Levonen
Research23 Aug 2019
Oncogene

Volume: 38, P: 7473-7490

Search

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Insulin Autoantibody Isotypes during the Prediabetic Process in Young Children with Increased Genetic Risk of Type 1 Diabetes

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

Establishing a GMP-compliant manufacturing process and phase-appropriate analytics for early development of a FiCAR T-cell product with a novel CAR spacer

Measurement of the nucleation of atmospheric aerosol particles

Automated and closed clinical-grade manufacturing protocol produces potent NK cells against neuroblastoma cells and AML blasts

Association of body-mass index with physiological brain pulsations across adulthood – a fast fMRI study

Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

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