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Showing 1–5 of 5 results
Advanced filters: Author: Mattia Silvi Clear advanced filters
  • An unconventional route for modifying pharmaceutically relevant molecules swaps an atom of carbon for one of nitrogen. The resulting derivatives might open up avenues of research in medicinal-chemistry campaigns.

    • Filippo Ficarra
    • Mattia Silvi
    News & Views
    Nature
    Volume: 623, P: 36-37
  • This Review discusses recent developments in the combination of organocatalysis and photochemistry for the activation of molecules, which has enabled previously inaccessible reaction pathways and influenced many fields of chemical research.

    • Mattia Silvi
    • Paolo Melchiorre
    Reviews
    Nature
    Volume: 554, P: 41-49
  • A conjunctive olefination between aldehydes and carboxylic acids has been developed by merging photoredox catalysis with the Wittig reaction. The process uses a readily available phosphonium salt to join together complex molecular fragments with high functional group tolerance and minimal use of protecting groups, enabling access to coupling products with user-defined geometries.

    • Dario Filippini
    • Mattia Silvi
    Research
    Nature Chemistry
    Volume: 14, P: 66-70
  • Chiral iminium ions generated from an amine catalyst and enals are key organocatalytic intermediates in thermal asymmetric processes. Now, visible-light excitation of these iminium ions can turn these compounds into strong oxidants to enable enantioselective photochemical β-alkylations of enals with silanes, which are unachievable via conventional ground state pathways.

    • Mattia Silvi
    • Charlie Verrier
    • Paolo Melchiorre
    Research
    Nature Chemistry
    Volume: 9, P: 868-873