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Showing 1–2 of 2 results
Advanced filters: Author: Maura Mingoia Clear advanced filters

  • Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and suggest that its high frequency in Sardinia was driven by past endemic malaria.

    • Maria Giuseppina Marini
    • Maura Mingoia
    • Francesco Cucca
    ResearchOpen Access
    Nature
    P: 1-9

  • A gene therapy phase 1 trial in patients with β-thalassemia shows transplantation of autologous CD34+ cells transduced with a lentiviral globin vector after reduced-intensity conditioning achieves long-term engraftment, albeit not transfusion independence, with benign clonal expansions, warranting cautious monitoring of patients.

    • Farid Boulad
    • Aurelio Maggio
    • Michel Sadelain
    Research
    Nature Medicine
    Volume: 28, P: 63-70