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Showing 1–4 of 4 results
Advanced filters: Author: Maurizio Mangolini Clear advanced filters

  • The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-survival bidirectional crosstalk between stromal cells and leukemic cells.

    • Maurizio Mangolini
    • Frederik Götte
    • Ingo Ringshausen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand and supply imbalance through loss of TCA energetics and thus, sensitises cells to apoptosis.

    • Joy Edwards-Hicks
    • Huizhong Su
    • Andrew J. Finch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • NOTCH mutations are frequent in B cell malignancies. Here the authors use retroviral transduction of primary malignant B cells from Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) patients to show that NOTCH1/2-mutations facilitate mechanism of immune escape.

    • Maurizio Mangolini
    • Alba Maiques-Diaz
    • Ingo Ringshausen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21