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Controlling the coherent evolution of cavity quantum electrodynamics systems is key for future quantum networks. Here Pagliano et al.demonstrate dynamic control of the coupling of a single exciton to a photonic micro-resonator using electrical tuning of the exciton energy in a photonic crystal cavity diode.

The mechanisms driving epithelial regeneration in the colon are not well understood. Here, the authors show that IFN-γ, produced by immune cells in response to chemically induced colitis, acts as a central driver of crypt reorganization by inducing apoptosis and extrusion of BMP2-expressing colonocytes.

Alborzinia et al. report that MYCN-amplified neuroblastoma undergoes ferroptosis in the absence of intracellular cysteine, suggesting a combination of cysteine depletion and concomitant GPX4 inactivation as a potential therapeutic approach.

Transcriptional adaptation upregulates UTRN in Duchenne muscular dystrophy (DMD) patients, as supported by several lines of evidence, including the use of splice-switching antisense oligonucleotides to induce the skipping of out-of-frame exons of the DMD gene.

Inhibition of YBX1, a downstream target of the Janus kinase JAK2, sensitizes myeloproliferative neoplasm cells to JAK and could provide a means to eradicate such cells in human haematopoietic cancers.

Correction of disease-causing large genomic inversions remains challenging. Here, the authors developed a dual designer-recombinase system (RecF8) that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A.

Using quantum gas microscopy, Hilbert space fragmentation and fractonic excitations are observed in a two-dimensional tilted Bose–Hubbard model.

Bicaudal-D is an evolutionary conserved dynein adaptor protein, and missense mutations in this protein are associated with spinal muscular atrophy (SMA). Here, Jaarsma et al.show that Bicaudal-D also plays an essential role in controlling neuronal migration and lamination in the developing mouse cerebellum.

A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.

Authors present a comparative immunological characterisation of Chlamydia vaccine, CTH522/CAF®01, in mice and humans. Findings suggest the mouse to be a good predictor of human immunity to the Chlamydia vaccine CTH522/CAF®01, and long-lasting protection in the mouse further supports the development of this promising vaccine candidate.

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic lateral sclerosis-associated FUS and TDP-43 mutants.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

Cilia are composed of cytoskeletal filaments and molecular motors and are characterized by a wave-like motion. Here the authors show that this motion is reconstituted in vitro from the self-assembly of polymerizing actin filaments and myosin motors.

Human parainfluenza viruses are important respiratory pathogens. Here, the authors develop a robust mouse infection model that upon HPIV-3 infection exhibits viral replication, viral tropism to ciliated cells and club cells and marked lung pathology. Treatment with GS-441524 reduces virus-induced pathology.

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue proteins that regulate transcription elongation by docking onto phosphorylated serine-2 in the C-terminal domain (CTD) of Pol II through their SPOC domains. Here the authors characterize the interplay of these proteins and show that they coregulate neuronal target genes.

This study reveals that a substantial number of transcripts that are currently annotated as graft-mobile lack statistical support from available RNA-seq data.

Artificial microswimmers can emulate the autonomous regulation of chemotactic motility of living organisms. Frank et al. realize a chemotactic locomotion of emulsion droplets, composed of two phase-separated fluids, that can be reversibly directed up or down a chemical concentration gradient.

Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is crucial for heart function. Here, the authors characterize cMyBP-C dephosphorylation by PP1 and PP2A, developing a kinetic model that integrates kinase and phosphatase activities, revealing their distinct roles in health and heart disease.

Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca²⁺ channels in inner hair cells.

Modern vision-based language models face challenges with complex physical interactions, causal reasoning and intuitive psychology. Schulze Buschoff and colleagues demonstrate that while some models exhibit proficient visual data processing capabilities, they fall short of human performance in these cognitive domains.

The first experimental demonstration of saturable absorption in core-electron transitions in aluminium paves the way for investigating warm dense matter, which potentially has an important role in planetary science and the realization of inertial confinement fusion.

A photoswitchable diacylglycerol enables spatiotemporal control of membrane translocation of C1-domain-containing proteins and protein kinase C activation to modulate calcium oscillations and vesicle release for synaptic transmission.

An extreme Einstein ring ~10,000 times as bright as the Milky Way in the infrared is studied with VLT/ERIS and ALMA, and the authors find that the lensed galaxy is a starburst with a fast-rotating disk, rather than being driven by a major merger.

TAp63α monitors the genome integrity in oocytes. After DNA damage, TAp63α is activated, involving multiple phosphorylation steps by CK1 with different kinetics due to an unusual CK1/TAp63α interaction in which the product of one step inhibits the next.

The selective hydrogenation of trace acetylene to ethylene is a well-established process for purifying fossil-derived ethylene streams. Here, the authors present a self-repairing Pd-C laterally condensed catalyst that improves selectivity, prevents sub-surface hydride formation, and achieves high ethylene productivity, effectively bridging the gap between powder catalysts and single-crystal model catalysts.

Although intermetallic compounds and alloys feature metal atoms bonded solely to other metal atoms, this motif is unusual in molecular compounds. Now, three compounds with lanthanide metals surrounded by transition metal atoms have been made. Although reactive, they mimic intermetallic bonding and form a conceptual link from coordination compounds.

The extreme fields generated when a high-intensity laser or relativistic electron passes through a plasma offer the potential to accelerate particles over shorter distances than is possible with conventional accelerators. A new study suggests that driving a plasma with protons rather than electrons could be the key to generating TeV electron beams by this process.

A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.

Experimental observation of intersubband transitions in van der Waals quantum wells is enabled by high spatial resolution imaging through near-field optical microscopy.

A plume of water vapour and icy particles originates near the south pole of Saturn's moon Enceladus, but the grains are moving more slowly than the vapour, which has been difficult to understand. It is shown that repeated wall collisions of grains, with re-acceleration by the gas, induce an effective friction, offering a natural explanation for the reduced grain velocity. Particle speed and size distributions that reproduce the observed and inferred properties of the dust plume are derived.

Efficient organic light-emitting diodes require a multilayer architecture to confine charge recombination to the emissive layer. Here, authors demonstrate efficient single-layer devices for emitters with imbalanced charge transport without the need of additional charge transport or blocking layers.

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by myosin.