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Showing 1–2 of 2 results
Advanced filters: Author: Maxime Culot Clear advanced filters

  • In vitromodels of the blood–brain barrier (BBB) allow predictions of brain uptake for candidate drugs. Providing guidance through the plethora of BBB models, the authors discuss the pros and cons of different models, and their applications at various stages of drug discovery and development.

    • Romeo Cecchelli
    • Vincent Berezowski
    • Laurence Fenart
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 650-661

  • Inhibiting insulin-degrading enzyme (IDE) has been proposed as a potential therapeutic strategy for the treatment of patients with diabetes. Here, the authors develop a novel IDE inhibitor but find that, surprisingly, IDE inhibition has negative effects on glucose tolerance in mice.

    • Rebecca Deprez-Poulain
    • Nathalie Hennuyer
    • Benoit Deprez
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13