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Showing 1–14 of 14 results
Advanced filters: Author: Maxime Rotival Clear advanced filters

  • Population differences in immune responses to SARS-CoV-2 can be explained by environmental exposures, but also by local adaptation acting through genetic variants acquired after admixture with archaic hominin forms.

    • Yann Aquino
    • Aurélie Bisiaux
    • Lluis Quintana-Murci
    ResearchOpen Access
    Nature
    Volume: 621, P: 120-128

  • Machine-learning-based prediction of splicing in extinct hominin species highlights the effect of natural selection on splice-altering variants and reveals phenotypic differences with modern humans.

    • Maxime Rotival
    News & Views
    Nature Ecology & Evolution
    Volume: 7, P: 800-801

  • Alternative polyadenylation (APA) has a key role in the post-transcriptional regulation of most human genes but is understudied in cells of the immune system. Here, the authors construct an atlas of cell type-specific APA events in various immune cell-types and stimulation conditions, providing evidence of widespread stimulation-responsiveness and association with immune-related traits.

    • Lei Li
    • Xuelian Ma
    • Wei Li
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • A survey of 136 factors that may influence cytokine secretion identify smoking, cytomegalovirus latent infection and body mass index as influential factors, with varying effects on innate and adaptive immunity.

    • Violaine Saint-André
    • Bruno Charbit
    • Christophe Zimmer
    ResearchOpen Access
    Nature
    Volume: 626, P: 827-835

  • Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shuttling and transcriptional activity of SMAD2 in the diseased heart.

    • Huimei Chen
    • Aida Moreno-Moral
    • Enrico Petretto
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.

    • Mao Wang
    • Patrick Sips
    • Stuart A Cook
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 (SESN3) as a positive regulator of the disease.

    • Michael R. Johnson
    • Jacques Behmoaras
    • Enrico Petretto
    Research
    Nature Communications
    Volume: 6, P: 1-11

  • Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.

    • Jacob Bergstedt
    • Sadoune Ait Kaci Azzou
    • Lluis Quintana-Murci
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Genetic and environmental factors affect genome-wide patterns of epigenetic variation. Here, the authors show that while current habitat and historical lifestyle impact the methylome of rainforest hunter-gatherers and sedentary farmers, the biological functions affected and the degree of genetic control differ.

    • Maud Fagny
    • Etienne Patin
    • Lluis Quintana-Murci
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Impairment of cognitive function is a common feature of many neurodevelopmental disorders. Systems genetics analysis in the brain uncovered a convergent gene network for both cognition and neurodevelopmental disorders. As the network does not recapitulate known pathways, this finding represents a new basis for understanding factors influencing normal and disordered cognition.

    • Michael R Johnson
    • Kirill Shkura
    • Enrico Petretto
    Research
    Nature Neuroscience
    Volume: 19, P: 223-232

  • Here, a combination of genetic studies of gene expression, cross-species network analysis and genome-wide association studies has been used to identify gene networks and the loci underlying their regulation in rats. The results show that an inflammatory network driven by interferon regulatory factor 7 contributes to susceptibility to type 1 diabetes, and implicate the innate viral-response pathway and macrophages in the aetiology of this disease.

    • Matthias Heinig
    • Enrico Petretto
    • Stuart A. Cook
    Research
    Nature
    Volume: 467, P: 460-464