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Showing 1–2 of 2 results
Advanced filters: Author: Maximilian Bielohuby Clear advanced filters

  • The murine G protein-coupled receptor 83 (Gpr83) is expressed widely in the brain, but its physiological role is largely unknown. Here Müller et al.show that Gpr83 regulates systemic energy metabolism in part by modulating ghrelin signalling in the arcuate nucleus of the hypothalamus.

    • Timo D. Müller
    • Anne Müller
    • Matthias H. Tschöp
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-8

  • Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.

    • Chun-Xia Yi
    • Marc Walter
    • Matthias H. Tschöp
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9