Nature Search

Author Correction: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

Bennett W. Fox
Maximilian J. Helf
Frank C. Schroeder
Amendments and CorrectionsOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1
Correction: Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire

Micheal C. Wilson
Tetsushi Mori
Jörn Piel
Amendments and Corrections12 Mar 2014
Nature

Volume: 507, P: 262
Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

Fatty acid desaturation is central to metazoan lipid metabolism. Here, using C. elegans as a model, the authors show that both endogenous and microbiota-dependent small molecule signals converge to promote lipid desaturation via the nuclear receptor NHR-49/PPARα.

Bennett W. Fox
Maximilian J. Helf
Frank C. Schroeder
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans

Untargeted mass spectrometry-based metabolomics can reveal new biochemistry, but data analysis is challenging. Here, the authors develop Metaboseek, an open-source software that facilitates metabolite discovery, and apply it to characterize fatty acid alpha-oxidation in C. elegans.

Maximilian J. Helf
Bennett W. Fox
Frank C. Schroeder
ResearchOpen Access10 Feb 2022
Nature Communications

Volume: 13, P: 1-11
An environmental bacterial taxon with a large and distinct metabolic repertoire

Single-cell- and metagenomics-based study reveals two members of the candidate genus ‘Entotheonella’, symbionts of the marine sponge Theonella swinhoei; distinct biosynthetic gene clusters that account for most of the bioactive polyketides and peptides known from T. swinhoei are shown to be attributable to a single member of the T. swinhoei Y microbiome.

Micheal C. Wilson
Tetsushi Mori
Jörn Piel
ResearchOpen Access29 Jan 2014
Nature

Volume: 506, P: 58-62
Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Polytheonamides are giant peptide toxins produced by the uncultivated sponge bacterium Entotheonella factor. The biosynthesis of polytheonamides involves up to 50 post-translational modifications. Now, heterologous expression in Escherichia coli and Rhizobium hosts have shown that a minimalistic, iterative enzyme set introduces this exceptional molecular complexity via epimerizations, C-/N-methylations, hydroxylations, dehydration and proteolytic maturation.

Michael F. Freeman
Maximilian J. Helf
Jörn Piel
Research28 Nov 2016
Nature Chemistry

Volume: 9, P: 387-395
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics.

Daniel B. Lipka
Tania Witte
Christoph Plass
ResearchOpen Access19 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Characterization of the gene cluster for omphalotin biosynthesis reveals that they are ribosomally synthesized peptides whose internal α-N-methyl groups are installed by a methyltransferase fused to the precursor peptide substrate.

Niels S van der Velden
Noemi Kälin
Markus Künzler
Research05 Jun 2017
Nature Chemical Biology

Volume: 13, P: 833-835

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Author Correction: Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

Correction: Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire

Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans

An environmental bacterial taxon with a large and distinct metabolic repertoire

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

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