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Showing 1–8 of 8 results
Advanced filters: Author: Maya Lotan-Pompan Clear advanced filters

  • Deep phenotyping of an ancestrally diverse group of 13,000 individuals in the Human Phenotype Project highlights diversity and variations in lifestyle factors, clinical features and molecular signatures of health and disease.

    • Lee Reicher
    • Smadar Shilo
    • Eran Segal
    Research
    Nature Medicine
    Volume: 31, P: 3191-3203

  • The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

    • Noam Bar
    • Tal Korem
    • Eran Segal
    Research
    Nature
    Volume: 588, P: 135-140

  • HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.

    • Shelly Kalaora
    • Adi Nagler
    • Yardena Samuels
    Research
    Nature
    Volume: 592, P: 138-143

  • Here, analyzing data from a six-month clinical trial in pre-diabetes, the authors found 166 of 2,803 measured features, including oral and gut microbiome, metabolites and cytokines, significantly changed in response to dietary interventions; highlighting the microbiome’s role in cardiometabolic health and revealing potential therapeutic avenues.

    • Saar Shoer
    • Smadar Shilo
    • Eran Segal
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The authors systematically characterize structural variation in the genomes of gut microbiota and show that they are associated with bacterial fitness and with host risk factors, and that examining genes coded in these regions facilitates investigation of mechanisms that may underlie these associations.

    • David Zeevi
    • Tal Korem
    • Eran Segal
    Research
    Nature
    Volume: 568, P: 43-48

  • Statistical analyses of a metagenomics-sequenced human cohort identify a relatively minor role for genetics in determining microbiome composition and show that several human phenotypes are as strongly associated with the gut microbiome as with host genetics.

    • Daphna Rothschild
    • Omer Weissbrod
    • Eran Segal
    Research
    Nature
    Volume: 555, P: 210-215

  • Eran Segal and colleagues measure the promoter activities of 70 different constructed promoter variants and find that poly(dA:dT) tracts significantly affect transcriptional outcome. They suggest that this is mediated by altering nucleosome organization and that these sequences can be manipulated to fine tune regulation of gene expression.

    • Tali Raveh-Sadka
    • Michal Levo
    • Eran Segal
    Research
    Nature Genetics
    Volume: 44, P: 743-750