Here, the authors show that although transcription is severely diminished in nucleated erythrocytes, it persists at genes involved in promoter-proximal pausing of RNA polymerase II. Erythrocyte nuclei exhibit a reoriented architecture with accessible chromatin at the periphery and retain chromatin organization at minidomains surrounding RNA polymerase II-paused gene promoters.
- Andrés Penagos-Puig
- Sherlyn Claudio-Galeana
- Mayra Furlan-Magaril
