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Advanced filters: Author: McAnthony Tarway Clear advanced filters

  • Ludmila Prokunina-Olsson, Thomas O'Brien and colleagues report the discovery of a new gene, INFL4, encoding interferon-λ4, that is upstream of INFL3 (IL28B). A compound dinucleotide frameshift genetic variant in INFL4 creates the full-length INFL4 protein and is more strongly associated with hepatitis C virus clearance in individuals of African ancestry than rs12979860, a known variant associated with clearance.

    • Ludmila Prokunina-Olsson
    • Brian Muchmore
    • Thomas R O'Brien
    Research
    Nature Genetics
    Volume: 45, P: 164-171