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Showing 1–4 of 4 results
Advanced filters: Author: Meagan R. Rollins Clear advanced filters

  • The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which uncovers that the natural genomic context for TCRs can enhance the antigen sensitivity of lower affinity TCRs and enables the physiologic range of antigen-TCR interaction and a gene dosage dependent mechanism of central tolerance.

    • Meagan R. Rollins
    • Jackson F. Raynor
    • Ingunn M. Stromnes
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated with tissue residency and improved anti-tumor immune response in a preclinical model of prostate cancer.

    • Brandon J. Burbach
    • Stephen D. O’Flanagan
    • Yoji Shimizu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Here the authors assess neutralizing antibody (nAb) levels as correlate of protection in a monoclonal antibody prevention trial and a vaccine trial for COVID-19 and show that nAb titers correlate with clinical protection against COVID-19 supporting nAb titer as a surrogate endpoint for authorization of monoclonal antibodies.

    • Dean Follmann
    • Meagan P. O’Brien
    • Myron S. Cohen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • The Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types; these data were compared with those from human to confirm substantial conservation in the newly annotated potential functional sequences and to reveal pronounced divergence of other sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization.

    • Feng Yue
    • Yong Cheng
    • Bing Ren
    ResearchOpen Access
    Nature
    Volume: 515, P: 355-364