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Showing 1–5 of 5 results
Advanced filters: Author: Meera Trisal Clear advanced filters

  • Profiling the immune responses of 56 volunteers vaccinated with BNT162b2 reveals how this mRNA vaccine primes the innate immune system to mount a potent response to SARS-CoV-2 after booster immunization.

    • Prabhu S. Arunachalam
    • Madeleine K. D. Scott
    • Bali Pulendran
    Research
    Nature
    Volume: 596, P: 410-416

  • Trials in rhesus macaques show that a subunit vaccine against SARS-CoV-2, comprising the spike protein receptor-binding domain displayed on a nanoparticle protein scaffold, produces a robust protective response against the virus.

    • Prabhu S. Arunachalam
    • Alexandra C. Walls
    • Bali Pulendran
    Research
    Nature
    Volume: 594, P: 253-258

  • The regulatory protein SREBP is required for CD8+ T cell metabolic reprogramming after activation. Luo et al. demonstrate that stimulated B cells require SCAP, a regulator of SREBP, for metabolic reprogramming and the formation and maintenance of germinal center B cells.

    • Wei Luo
    • Julia Z. Adamska
    • Bali Pulendran
    Research
    Nature Immunology
    Volume: 24, P: 337-348

  • How mRNA-based coronavirus disease 2019 vaccines drive immune responses is not clear. Here the authors characterize immune responses to the BNT162b2 vaccine in mice, and show how it stimulates innate immunity, with antigen-specific CD8+ T cell responses dependent on the RNA sensor MDA5.

    • Chunfeng Li
    • Audrey Lee
    • Bali Pulendran
    Research
    Nature Immunology
    Volume: 23, P: 543-555