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Showing 1–5 of 5 results
Advanced filters: Author: Meghan R Wyatt Clear advanced filters

  • Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

    • Michael E. Dunn
    • Aaron Kithcart
    • Lori Morton
    ResearchOpen Access
    Nature
    Volume: 633, P: 654-661

  • A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

    • Aljoscha Nern
    • Frank Loesche
    • Michael B. Reiser
    ResearchOpen Access
    Nature
    Volume: 641, P: 1225-1237

  • CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and variable sgRNA activity. Applying CERES to new genome-scale CRISPR–Cas9 essentiality screen data from 342 cancer cell lines and other published data sets shows that CERES decreases false-positive results and provides consistent estimates of sgRNA activity.

    • Robin M Meyers
    • Jordan G Bryan
    • Aviad Tsherniak
    Research
    Nature Genetics
    Volume: 49, P: 1779-1784

  • Liquid biopsy techniques, especially the use of plasma circulating tumour DNA (ctDNA) analysis, are a convenient, fast and non-invasive approach to the diagnosis and monitoring of urological cancers, and could enable selection of targeted therapy before clinical and radiographic changes occur. In this Review, the authors discuss the uses of liquid biopsy and plasma ctDNA analysis in particular, and consider how it could be used in clinical practice now and in the future.

    • Manuel Caitano Maia
    • Meghan Salgia
    • Sumanta K. Pal
    Reviews
    Nature Reviews Urology
    Volume: 17, P: 271-291

  • The authors present a protocol for genome-wide clustered regularly interspaced short palindromic repeat screening of three-dimensional neurospheres.

    • Tanaz Abid
    • Amy B. Goodale
    • David E. Root
    Protocols
    Nature Protocols
    Volume: 18, P: 2014-2031