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Showing 1–3 of 3 results

Advanced filters: Author: Mehrdad Zarei Clear advanced filters

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Winter and colleagues demonstrate that metabolic adaptation to nutrient stress in the tumor microenvironment of pancreatic cancer leads to a dependency on IDH1, which is therapeutically actionable regardless of IDH1 mutation status.

Ali Vaziri-Gohar
Joel Cassel
Jordan M. Winter
ResearchOpen Access09 Jun 2022
Nature Cancer

Volume: 3, P: 852-865
Increased glucose availability sensitizes pancreatic cancer to chemotherapy

Response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) is often limited. Here, the authors report improved response to chemotherapy in PDAC patients with hyperglycaemia and investigate the underlying mechanism via glucose-mediated disruption of redox metabolism

Ali Vaziri-Gohar
Jonathan J. Hue
Jordan M. Winter
ResearchOpen Access28 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Formulation of low temperature mixed mode crack propagation behavior of crumb rubber modified HMA using artificial intelligence

Sepehr Ghafari
Mehrdad Ehsani
Fereidoon Moghadas Nejad
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-25