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Showing 1–9 of 9 results

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Author Correction: NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity

Meidi Gu
Xiaofei Zhou
Shao-Cong Sun
Amendments and Corrections11 Feb 2021
Nature Immunology

Volume: 22, P: 530
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity

Metabolic rewiring of cytotoxic T lymphocytes (CTLs) can impair their antitumor functions. Sun and colleagues demonstrate that CTL-intrinsic activity of the kinase NIK is essential for CTL metabolic fitness in the tumor microenvironment.

Meidi Gu
Xiaofei Zhou
Shao-Cong Sun
Research04 Jan 2021
Nature Immunology

Volume: 22, P: 193-204
Dapl1 controls NFATc2 activation to regulate CD8⁺ T cell exhaustion and responses in chronic infection and cancer

Zhu et al. identify Dapl1 as a negative regulator of CD8⁺ T cell responses by modulating NFATc2 activation and T cell exhaustion, leading to dysregulated control of chronic infection and cancer.

Lele Zhu
Xiaofei Zhou
Shao-Cong Sun
Research30 Jun 2022
Nature Cell Biology

Volume: 24, P: 1165-1176
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

Zhu et al. show that, in response to growth factors, TBKBP1 recruits TBK1 to promote its activation by PKCθ, thereby facilitating mTORC1 activation, tumour-mediated immunosuppression and tumourigenesis.

Lele Zhu
Yanchuan Li
Shao-Cong Sun
Research02 Dec 2019
Nature Cell Biology

Volume: 21, P: 1604-1614
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

The kinase NIK activates a noncanonical NF-κB2 signaling pathway. Shao-Cong Sun and colleagues show that conditional loss of NIK in dendritic cells alters gut microbiome composition and T_H17 cell responses, as a result of reduced expression of IL-23, pIgR and fecal IgA transcytosis.

Zuliang Jie
Jin-Young Yang
Shao-Cong Sun
Research24 Sept 2018
Nature Immunology

Volume: 19, P: 1224-1235
Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.

Zhiyong Liu
Qiang Qin
Xiaojian Wang
ResearchOpen Access17 Jul 2018
Nature Communications

Volume: 9, P: 1-16
Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization

Yanchuan Li
Jin-Young Yang
Shao-Cong Sun
Research13 May 2019
Cell Research

Volume: 29, P: 474-485
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells

Xiaoping Xie
Lele Zhu
Shao-Cong Sun
Research17 Nov 2020
Cellular & Molecular Immunology

Volume: 18, P: 2262-2274
Lymphatic endothelial cells regulate B-cell homing to lymph nodes via a NIK-dependent mechanism

Jie Yang
Siya Zhang
Shao-Cong Sun
Research05 Mar 2018
Cellular & Molecular Immunology

Volume: 16, P: 165-177