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Advanced filters: Author: Meir Wetzler Clear advanced filters

  • Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

    • Jan Krönke
    • Emma C. Fink
    • Benjamin L. Ebert
    Research
    Nature
    Volume: 523, P: 183-188