The tumor microenvironment (TME) is complex and heterogenous, with cancer cells and diverse non-malignant cells interacting with each other. Here the authors define the network of interactions between different cell types in the TME of breast cancer, identifying and characterizing a two-cell circuit of cancer associated fibroblasts and macrophages.
- Shimrit Mayer
- Tomer Milo
- Ruth Scherz-Shouval
