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Showing 1–7 of 7 results
Advanced filters: Author: Melanie Ecker Clear advanced filters

  • The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.

    • Marcel P. Trefny
    • Nicole Kirchhammer
    • Alfred Zippelius
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

    • Christian Koelsche
    • Daniel Schrimpf
    • Andreas von Deimling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Thirteen pharmaceutical companies have shared and integrated preclinical and clinical data for creating computational resources that enhance translational drug safety assessment.

    • Ferran Sanz
    • François Pognan
    • David Wilkinson
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 22, P: 605-606

  • Results of an exploratory interim analysis from a phase I trial show that an RNA vaccine targeted towards four melanoma-associated antigens produces durable objective responses in patients with melanoma that are accompanied by strong CD4+ and CD8+ T-cell immunity.

    • Ugur Sahin
    • Petra Oehm
    • Özlem Türeci
    Research
    Nature
    Volume: 585, P: 107-112

  • The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.

    • Giulio Superti-Furga
    • Daniel Lackner
    • Claire M. Steppan
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 19, P: 429-430